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Metabolomic signatures of aggressive prostate cancer Prostate 2013 73(14):1547-1560 20 Thysell E Surowiec I Hornberg E et al Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol PLoS One 2010 5(12):e14175 21 Wu X Daniels G Lee P et al Lipid metabolism in prostate cancer
For germline BRCA2 mutation carriers the relative risk of developing prostate cancer by age 65 years is estimated to be 2 5- to 8 6-fold compared with noncarriers 19 In a recent study lifetime risk of prostate cancer by age 80 years was reported between 19% and 61% and 7% and 26% for carriers of BRCA2 and BRCA1 mutations respectively 20 Retrospective studies have shown that men with
1 Introduction Prostate cancer is the second most common male cancer in the world with a total of 1 111 700 new cases and 307 500 deaths estimated in 2012 The most well-established risk factors for prostate cancer are age race/ethnicity and family history of prostate cancer Physical activities coffee consumption statin use intake of certain vegetables also have been linked with the
-some of the 2 most common histologic grades in a prostate tumor and correlates with prognosis-a higher score is more likely to be seen with disease that is not confined to the prostate and is correlated with poorer response to treatment of localized disease Symptoms of prostate cancer *Local growth*-rarely causes symptoms-may present with symptoms of bladder outlet obstruction/acute urinary
Metastatic or recurrent tumors are the primary cause of cancer-related death For prostate cancer patients diagnosed with local disease have a 99% 5-year survival rate however this 5-year survival rate drops to 28% in patients with metastatic disease This dramatic decline in survival has driven interest in discovering new markers able to identify tumors likely to recur and in developing
Cardiovascular Safety of Degarelix Versus Leuprolide for Advanced Prostate Cancer: The PRONOUNCE Trial Study Design The main prostate cancer-related objectives are to monitor testosterone levels on days 28 168 and 336 to evaluate the progression-free survival failure rates (defined as either death radiographic disease progression introduction of additional prostate cancer
Cancer-related fatigue is one of the most prevalent prolonged and distressing side effects of prostate cancer treatment with androgen deprivation therapy Preliminary evidence suggests natural therapies such as nutrition therapy and structured exercise prescription can reduce symptoms of cancer-related fatigue Men appear to change their habitual dietary patterns after prostate cancer
Prostate cancer mortality rates are highest among men of African ancestry in the United States and globally Environmental exposures and ancestry-related factors may influence tumor biology and induce a more aggressive disease in this population Here we summarize the most recent advances in our understanding of race/ethnic differences in the tumor biology of prostate cancer with an emphasis
Extracellular vesicles: the next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis Bairen Pang 1 2 Ying Zhu 1 2 Jie Ni 1 2 James Thompson 1 3 4 David Malouf 2 3 Joseph Bucci 1 2 Peter Graham 1 2 Yong Li 1 2 5 1 St George and Sutherland Clinical School Faculty of Medicine University of New South Wales
Steginga et al undertook a survey of 1224 men previously treated for prostate cancer who were members of prostate cancer support groups affiliated with the Prostate Cancer Foundation of Australia This level IV study found high levels of satisfaction with the support provided by these groups with no differences in satisfaction between professionally- or peer-led groups The strongest
Parthenolide Inhibits Prostate Cancer Related Osteoclast Survival In Vitro Next we went on to carry out additional experiments on the effects of PTN on mature osteoclast activity and survival Mature osteoclasts were generated in RANKL and M-CSF stimulated bone marrow macrophage cultures for 3 days and then exposed to rat Mat-Ly-Lu conditioned medium (20% v/v) in the presence and absence
For germline BRCA2 mutation carriers the relative risk of developing prostate cancer by age 65 years is estimated to be 2 5- to 8 6-fold compared with noncarriers 19 In a recent study lifetime risk of prostate cancer by age 80 years was reported between 19% and 61% and 7% and 26% for carriers of BRCA2 and BRCA1 mutations respectively 20 Retrospective studies have shown that men with
Introduction Prostate cancer is the third most frequent cause of cancer death in developed countries 1 PSA screening has been introduced with the aim of reducing prostate cancer‐related mortality but the incidence of prostate cancer has more than doubled since the introduction of serum PSA testing and half to two‐thirds of cases diagnosed by screening are thought to be over‐detected 2 3
Association Between Online Information-Seeking and Adherence to Guidelines for Breast and Prostate Cancer Screening ORIGINAL RESEARCH — Volume 15 — April 19 2018 Related Pages Hankyul Kim MSPH 1 Christopher Filson MD MS 2 3 Peter Joski MSPH 1 Silke von Esenwein PhD 1 Joseph Lipscomb PhD 1 3 (View author affiliations) Suggested citation for this article: Kim H Filson
As well as many widely used medical abbreviations this text includes abbreviations that have meaning only within oncology sub-specialities or even particular organisations No definitive list of standard abbreviations exists therefore it is important to understand the context in which they have been used in For example PNET usually refers to a type of brain tumour however within
List of Abbreviations The Role of Insulin in Advanced Prostate Cancer vii List of Abbreviations ADT – Androgen Deprivation Therapy BMI – Body Mass Index – equal to mass/ (height in metres) 2 CRPC - Castrate Resistant Prostate Cancer DES - Diethylstilboestrol DHT – Dihydrotestosterone GnRH – Gonadotrophin Releasing Hormone HDL – High Density Lipoprotein IGF-1 and IGF-2
Prostate cancer is the most commonly diagnosed cancer in black men and breast cancer is the most commonly diagnosed in black women each accounting for nearly one‐third of cancers diagnosed in each Cancers of the lung and colorectum are the second and third most commonly diagnosed cancers respectively in both black men and women Together the 4 most common cancers (breast prostate
Abbreviations: AR = androgen receptor BPH = benign prostatic hyperplasia CI = confidence interval OR = odds ratio PCPT = Prostate Cancer Prevention Trial PSA = prostate-specific antigen How to cite this article: Wang L Lei Y Gao Y Cui D Tang Q Li R Wang D Chen Y Zhang B Wang H Association of finasteride with prostate cancer : a systematic review and meta-analysis
Metabolomic signatures of aggressive prostate cancer Prostate 2013 73(14):1547-1560 20 Thysell E Surowiec I Hornberg E et al Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterol PLoS One 2010 5(12):e14175 21 Wu X Daniels G Lee P et al Lipid metabolism in prostate cancer
The association of germline mutations in the breast cancer susceptibility gene 1 (BRCA1) and the breast cancer susceptibility gene 2 (BRCA2) with the development of breast and ovarian cancers have been widely researched and recognised It is known that these genes function at multiple sites in the body Research has subsequently evolved into the connection of BRCA1/2 with cancers at other
Prostate cancer in Australia is the first comprehensive national report on prostate cancer in Australia It provides an overview of the condition its risk factors diagnosis and management and key summary measures including incidence mortality and survival Comparisons over time and by age selected population groups and international region are
Prostate cancer (PCa) is one of the most prevalent cancers that occur in men worldwide Autophagy-related genes (ARGs) may play an essential role in multiple biological processes of prostate cancer However ARGs expression signature has rarely been used to investigate the association between autophagy and prognosis in PCa This study aimed to identify and assess prognostic ARGs signature
Purpose To determine whether the use of statins after prostate cancer diagnosis is associated with a decreased risk of cancer-related mortality and all-cause mortality and to assess whether this association is modified by prediagnostic use of statins Patients and Methods A cohort of 11 772 men newly diagnosed with nonmetastatic prostate cancer between April 1 1998 and December 31 2009
Prostate cancer in Australia is the first comprehensive national report on prostate cancer in Australia It provides an overview of the condition its risk factors diagnosis and management and key summary measures including incidence mortality and survival Comparisons over time and by age selected population groups and international region are
Prostate adenocarcinoma is the second most frequent cancer worldwide and is one of the leading causes of male cancer-related deaths However it varies greatly in its behaviour from indolent non-progressive disease to metastatic cancers with high associated mortality The aim of this study was to identify predictive biomarkers for patients with localised prostate tumours most likely to
Introduction Prostate cancer will be diagnosed in approximately 240 890 US men in 2011 and an estimated 33 720 men will die from this disease 1 While the death rate has been decreasing somewhat over the last decade the absolute number of men with prostate cancer is projected to increase substantially as a result of the ageing baby boomer population
outcome of patients with prostate cancer and biochemical recurrence Inaugural-Dissertation zur Erlangung des Doktorgrades der Medizin der Medizinischen Fakultt der Eberhard Karls Universitt zu Tbingen vorgelegt von Avils Escobar Claudia Mara 2016 Dekan: Professor Dr I Autenrieth 1 Berichterstatter: Professor Dr J Bedke 2 Berichterstatter: Professor Dr U Lauer Para mis
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